Textbook of Diabetes
-15%
portes grátis
Textbook of Diabetes
Holt, Richard I. G.; Flyvbjerg, Allan
John Wiley and Sons Ltd
02/2024
1232
Dura
9781119697428
15 a 20 dias
Descrição não disponível.
List of Contributors, viii
Preface, xv
List of Abbreviations, xvi
Part 1 Diabetes in its Historical and Social Context
1 The History of Diabetes Mellitus, 3
Robert B. Tattersall and David R. Matthews
2 Classification and Diagnosis of Diabetes, 22
Ambady Ramachandran, Chamukuttan Snehalatha, Arun Raghavan, and Arun Nanditha
3 The Global Burden of Diabetes, 28
Jessica L. Harding, Mary Beth Weber, and Jonathan E. Shaw
4 Epidemiology of Type 1 Diabetes, 41
Lars C. Stene and Jaakko Tuomilehto
5 Epidemiology of Type 2 Diabetes, 55
Ronald C.W. Ma and Peter C.Y. Tong
Part 2 Normal Physiology
6 Overview of Glucose Metabolism, 77
Richard I.G. Holt
7 Islet Function and Insulin Secretion, 84
Peter M. Jones and Shanta J. Persaud
8 Glucagon in Islet and Metabolic Regulation, 99
Jonathan E. Campbell and David A. D'Alessio
9 Mechanism of Insulin Action, 111
Morris F. White
10 Central Control of Glucose Homeostasis, 128
Kimberly M. Alonge, Kendra L. Francis, Nicole E. Richardson, and Michael W. Schwartz
11 Control of Body Weight: How and Why Do We Gain Weight Easier Than We Lose It?, 142
Janine Makaronidis and Rachel L. Batterham
Part 3 Pathogenesis of Diabetes
12 The Genetics of Diabetes, 157
Rashmi B. Prasad
13 Genetics of Obesity, 197
I. Sadaf Farooqi
14 Autoimmune Type 1 Diabetes, 203
Omar Akel and Ake Lernmark
15 Other Disorders with Type 1 Diabetes and Atypical Phenotypes, 216
Alice P.S. Kong, Elaine Y.K. Chow, Andrea O.Y. Luk, and Juliana C.N. Chan
16 Abnormalities of Insulin Secretion and ?-Cell Defects in Type 2 Diabetes, 225
Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele
17 Insulin Resistance in Type 2 Diabetes, 238
Michael Roden, Kitt Falk Petersen, and Gerald I. Shulman
18 Obesity and Diabetes, 250
Nick Finer
19 The Microbiome and Diabetes, 261
Amanda J. Cox, Nicholas P. West, and Allan W. Cripps
Part 4 Other Types of Diabetes
20 Monogenic Causes of Diabetes, 275
Brittany L. Resnick, Maggie H. Shepherd, and Andrew T. Hattersley
21 Drug-Induced Diabetes, 295
Charles D. Ponte and Devra K. Dang
22 Diabetes in Hypersecreting Endocrine Disorders, 304
Allan A. Vaag, Neil A. Hanley, and Caroline M. Kistorp
23 Pancreatic Disease and Diabetes, 319
Ranjit Unnikrishnan and Viswanathan Mohan
24 Clinical Presentations of Diabetes, 330
Ee Lin Lim and Roy Taylor
Part 5 Managing the Person with Diabetes
25 The Aims of Diabetes Care, 343
Katharine D. Barnard-Kelly and Richard I.G. Holt
26 Education to Empower the Person with Diabetes, 354
Ingrid Willaing and Michael Vallis
27 Dietary Management of Diabetes, 368
Nicola Guess
28 Physical Activities and Diabetes, 382
Emma J. Cockcroft and Robert C. Andrews
29 Monitoring Diabetes, 404
Emma English
30 Biomarkers and Precision Medicine in Diabetes, 414
Sok Cin Tye, Michele Provenzano, and Hiddo J.L. Heerspink
Part 6 Treatment of Diabetes
31 Insulin and Insulin Treatment, 431
Roman Vangoitsenhoven, Parth Narendran, and Chantal Mathieu
32 New Technologies for Glucose Monitoring, 444
Thomas Danne and Olga Kordonouri
33 New Technologies for Insulin Administration, 459
Hannah Forde and Pratik Choudhary
34 Whole Pancreas and Islet Cell Transplantation, 473
Braulio A. Marfil-Garza, Peter A. Senior, and A.M. James Shapiro
35 Oral Glucose-Lowering Agents, 492
Clifford J. Bailey and Andrew J. Krentz
36 Non-insulin Parenteral Therapies, 520
Tina Vilsboll, Mikkel Christensen, Andreas Andersen, and Filip K. Knop
37 How to Use Type 2 Diabetes Treatments in Clinical Practice, 534
Thomas Karagiannis, Aris Liakos, and Apostolos Tsapas
38 Weight Management and Metabolic Surgery, 551
Alexis Sudlow, Dimitri J. Pournaras, and Carel W. le Roux
39 In-Hospital Treatment and Surgery in People with Diabetes, 559
Ketan Dhatariya, Philip Newland-Jones, and Mayank Patel
40 Hypoglycaemia in Diabetes, 579
Ahmed Iqbal, Elaine Y.K. Chow, Timothy W. Jones, and Simon R. Heller
41 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycaemic State in Adults, 602
Philip Newland-Jones, Mayank Patel, and Ketan Dhatariya
Part 7 Microvascular Complications in Diabetes
42 Pathogenesis of Microvascular Complications, 615
Allan Flyvbjerg
43 Diabetic Retinopathy, 629
Toke Bek
44 Diabetic Nephropathy, 640
Peter Rossing and Allan Flyvbjerg
45 Diabetic Neuropathy, 655
Shazli Azmi, Uazman Alam, and Rayaz A. Malik
Part 8 Macrovascular Complications in Diabetes
46 Pathogenesis of Macrovascular Complications in Diabetes, 681
Jakob A. Ostergaard, Tomasz J. Block, Sophia Dahm, Waheed Khan, and Karin A.M. Jandeleit-Dahm
47 Hypertension and Diabetes, 700
Peter M. Nilsson
48 Dyslipidaemia and Diabetes, 713
Adie Viljoen, Ahmed Handhle, and Anthony S. Wierzbicki
49 Ischaemic Heart Disease in Diabetes, 724
Michael Lehrke and Nikolaus Marx
50 Heart Failure and Diabetes, 732
Ambarish Pandey, Kershaw V. Patel, and Subodh Verma
51 Cerebrovascular Disease and Diabetes, 745
Colum F. Amory, Jesse Weinberger, and Travis S. Smith
52 Peripheral Vascular Disease, 755
Henrik H. Sillesen
Part 9 Other Complications of Diabetes
53 Foot Problems in People with Diabetes, 771
Frank L. Bowling, Keeley J. Foley, and Andrew J.M. Boulton
54 Sexual Function in Men and Women with Diabetes, 780
Kirsty Winkley, Camilla Kristensen, Jackie Fosbury, and David Price
55 Gastrointestinal Manifestations of Diabetes, 796
Michael Camilleri and Adil E. Bharucha
56 Diabetes and Oral Health, 810
Palle Holmstrup, Christian Damgaard, and Allan Flyvbjerg
57 Diabetes and Non-alcoholic Fatty Liver Disease, 820
Alessandro Mantovani, Giovanni Targher, and Christopher D. Byrne
58 The Skin in Diabetes, 838
Paul Devakar Yesudian
59 Bone and Rheumatic Disorders in Diabetes, 853
Andrew Grey and Nicola Dalbeth
60 Diabetes and Cancer: Risk, Outcomes, and Clinical Implications, 867
Ellena Badrick, Emily J. Gallagher, and Andrew G. Renehan
61 Diabetes and Infections, 878
Andrea O.Y. Luk and Clive S. Cockram
62 Sleep and Diabetes, 897
Sonya Deschenes, Amy McInerney, and Norbert Schmitz
Part 10 Psychosocial Aspects of Diabetes
63 Psychosocial and Behavioural Aspects of Diabetes, 907
Frans Pouwer and Jane Speight
64 Role of Cognitive Function in Managing People with Diabetes, 922
Tamsin Santos, Chelsea Baird, Sally Eastwood, Kerrie Shiell, and Joseph E. Ibrahim
65 Mental Disorders and Diabetes, 933
Najma Siddiqi, Marietta Stadler, and Richard I.G. Holt
66 Social Aspects of Diabetes, 956
Brian M. Frier and Mark W.J. Strachan
67 Social Determinants of Diabetes, 973
Keri F. Kirk, Gerald McKinley, Briana Mezuk, and Erica Spears
Part 11 Diabetes in Special Groups
68 Ethnic, Cultural, and Religious Aspects to the Management of Diabetes, 987
Wasim Hanif, Sarah N. Ali, and Vinod Patel
69 Diabetes in Childhood, 999
Jennifer M. Ikle, Ananta Addala, and David M. Maahs
70 Adolescence and Emerging Adulthood: Diabetesin Transition, 1019
Charlotte W. Chen and Lori M.B. Laffel
71 Diabetes in Pregnancy, 1034
David R. McCance and Laura Cassidy
72 Diabetes in Old Age, 1072
Ahmed H. Abdelhafiz and Alan J. Sinclair
73 Diabetes at the End of Life, 1085
Trisha Dunning and June James
Part 12 Delivery and Organization of Diabetes Care
74 The Role of the Multidisciplinary Team across Primary and Secondary Care, 1097
Samuel Seidu and Kamlesh Khunti
75 Models of Diabetes Care in Low-and Middle-Income Countries, 1107
David Beran, Sigiriya Aebischer Perone, and Maria Lazo-Porras
Part 13 Future Directions
76 Immunotherapies for Type 1 Diabetes, 1125
Jesper Johannesen and Flemming Pociot
77 Stem Cell Therapy in Diabetes, 1137
Angelo Avogaro and Gian Paolo Fadini
78 Gene Therapy for Diabetes, 1144
Veronica Jimenez and Fatima Bosch
79 Future Drug Treatments for Type 2 Diabetes, 1154
Clifford J. Bailey
Index, 1167
Preface, xv
List of Abbreviations, xvi
Part 1 Diabetes in its Historical and Social Context
1 The History of Diabetes Mellitus, 3
Robert B. Tattersall and David R. Matthews
2 Classification and Diagnosis of Diabetes, 22
Ambady Ramachandran, Chamukuttan Snehalatha, Arun Raghavan, and Arun Nanditha
3 The Global Burden of Diabetes, 28
Jessica L. Harding, Mary Beth Weber, and Jonathan E. Shaw
4 Epidemiology of Type 1 Diabetes, 41
Lars C. Stene and Jaakko Tuomilehto
5 Epidemiology of Type 2 Diabetes, 55
Ronald C.W. Ma and Peter C.Y. Tong
Part 2 Normal Physiology
6 Overview of Glucose Metabolism, 77
Richard I.G. Holt
7 Islet Function and Insulin Secretion, 84
Peter M. Jones and Shanta J. Persaud
8 Glucagon in Islet and Metabolic Regulation, 99
Jonathan E. Campbell and David A. D'Alessio
9 Mechanism of Insulin Action, 111
Morris F. White
10 Central Control of Glucose Homeostasis, 128
Kimberly M. Alonge, Kendra L. Francis, Nicole E. Richardson, and Michael W. Schwartz
11 Control of Body Weight: How and Why Do We Gain Weight Easier Than We Lose It?, 142
Janine Makaronidis and Rachel L. Batterham
Part 3 Pathogenesis of Diabetes
12 The Genetics of Diabetes, 157
Rashmi B. Prasad
13 Genetics of Obesity, 197
I. Sadaf Farooqi
14 Autoimmune Type 1 Diabetes, 203
Omar Akel and Ake Lernmark
15 Other Disorders with Type 1 Diabetes and Atypical Phenotypes, 216
Alice P.S. Kong, Elaine Y.K. Chow, Andrea O.Y. Luk, and Juliana C.N. Chan
16 Abnormalities of Insulin Secretion and ?-Cell Defects in Type 2 Diabetes, 225
Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele
17 Insulin Resistance in Type 2 Diabetes, 238
Michael Roden, Kitt Falk Petersen, and Gerald I. Shulman
18 Obesity and Diabetes, 250
Nick Finer
19 The Microbiome and Diabetes, 261
Amanda J. Cox, Nicholas P. West, and Allan W. Cripps
Part 4 Other Types of Diabetes
20 Monogenic Causes of Diabetes, 275
Brittany L. Resnick, Maggie H. Shepherd, and Andrew T. Hattersley
21 Drug-Induced Diabetes, 295
Charles D. Ponte and Devra K. Dang
22 Diabetes in Hypersecreting Endocrine Disorders, 304
Allan A. Vaag, Neil A. Hanley, and Caroline M. Kistorp
23 Pancreatic Disease and Diabetes, 319
Ranjit Unnikrishnan and Viswanathan Mohan
24 Clinical Presentations of Diabetes, 330
Ee Lin Lim and Roy Taylor
Part 5 Managing the Person with Diabetes
25 The Aims of Diabetes Care, 343
Katharine D. Barnard-Kelly and Richard I.G. Holt
26 Education to Empower the Person with Diabetes, 354
Ingrid Willaing and Michael Vallis
27 Dietary Management of Diabetes, 368
Nicola Guess
28 Physical Activities and Diabetes, 382
Emma J. Cockcroft and Robert C. Andrews
29 Monitoring Diabetes, 404
Emma English
30 Biomarkers and Precision Medicine in Diabetes, 414
Sok Cin Tye, Michele Provenzano, and Hiddo J.L. Heerspink
Part 6 Treatment of Diabetes
31 Insulin and Insulin Treatment, 431
Roman Vangoitsenhoven, Parth Narendran, and Chantal Mathieu
32 New Technologies for Glucose Monitoring, 444
Thomas Danne and Olga Kordonouri
33 New Technologies for Insulin Administration, 459
Hannah Forde and Pratik Choudhary
34 Whole Pancreas and Islet Cell Transplantation, 473
Braulio A. Marfil-Garza, Peter A. Senior, and A.M. James Shapiro
35 Oral Glucose-Lowering Agents, 492
Clifford J. Bailey and Andrew J. Krentz
36 Non-insulin Parenteral Therapies, 520
Tina Vilsboll, Mikkel Christensen, Andreas Andersen, and Filip K. Knop
37 How to Use Type 2 Diabetes Treatments in Clinical Practice, 534
Thomas Karagiannis, Aris Liakos, and Apostolos Tsapas
38 Weight Management and Metabolic Surgery, 551
Alexis Sudlow, Dimitri J. Pournaras, and Carel W. le Roux
39 In-Hospital Treatment and Surgery in People with Diabetes, 559
Ketan Dhatariya, Philip Newland-Jones, and Mayank Patel
40 Hypoglycaemia in Diabetes, 579
Ahmed Iqbal, Elaine Y.K. Chow, Timothy W. Jones, and Simon R. Heller
41 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycaemic State in Adults, 602
Philip Newland-Jones, Mayank Patel, and Ketan Dhatariya
Part 7 Microvascular Complications in Diabetes
42 Pathogenesis of Microvascular Complications, 615
Allan Flyvbjerg
43 Diabetic Retinopathy, 629
Toke Bek
44 Diabetic Nephropathy, 640
Peter Rossing and Allan Flyvbjerg
45 Diabetic Neuropathy, 655
Shazli Azmi, Uazman Alam, and Rayaz A. Malik
Part 8 Macrovascular Complications in Diabetes
46 Pathogenesis of Macrovascular Complications in Diabetes, 681
Jakob A. Ostergaard, Tomasz J. Block, Sophia Dahm, Waheed Khan, and Karin A.M. Jandeleit-Dahm
47 Hypertension and Diabetes, 700
Peter M. Nilsson
48 Dyslipidaemia and Diabetes, 713
Adie Viljoen, Ahmed Handhle, and Anthony S. Wierzbicki
49 Ischaemic Heart Disease in Diabetes, 724
Michael Lehrke and Nikolaus Marx
50 Heart Failure and Diabetes, 732
Ambarish Pandey, Kershaw V. Patel, and Subodh Verma
51 Cerebrovascular Disease and Diabetes, 745
Colum F. Amory, Jesse Weinberger, and Travis S. Smith
52 Peripheral Vascular Disease, 755
Henrik H. Sillesen
Part 9 Other Complications of Diabetes
53 Foot Problems in People with Diabetes, 771
Frank L. Bowling, Keeley J. Foley, and Andrew J.M. Boulton
54 Sexual Function in Men and Women with Diabetes, 780
Kirsty Winkley, Camilla Kristensen, Jackie Fosbury, and David Price
55 Gastrointestinal Manifestations of Diabetes, 796
Michael Camilleri and Adil E. Bharucha
56 Diabetes and Oral Health, 810
Palle Holmstrup, Christian Damgaard, and Allan Flyvbjerg
57 Diabetes and Non-alcoholic Fatty Liver Disease, 820
Alessandro Mantovani, Giovanni Targher, and Christopher D. Byrne
58 The Skin in Diabetes, 838
Paul Devakar Yesudian
59 Bone and Rheumatic Disorders in Diabetes, 853
Andrew Grey and Nicola Dalbeth
60 Diabetes and Cancer: Risk, Outcomes, and Clinical Implications, 867
Ellena Badrick, Emily J. Gallagher, and Andrew G. Renehan
61 Diabetes and Infections, 878
Andrea O.Y. Luk and Clive S. Cockram
62 Sleep and Diabetes, 897
Sonya Deschenes, Amy McInerney, and Norbert Schmitz
Part 10 Psychosocial Aspects of Diabetes
63 Psychosocial and Behavioural Aspects of Diabetes, 907
Frans Pouwer and Jane Speight
64 Role of Cognitive Function in Managing People with Diabetes, 922
Tamsin Santos, Chelsea Baird, Sally Eastwood, Kerrie Shiell, and Joseph E. Ibrahim
65 Mental Disorders and Diabetes, 933
Najma Siddiqi, Marietta Stadler, and Richard I.G. Holt
66 Social Aspects of Diabetes, 956
Brian M. Frier and Mark W.J. Strachan
67 Social Determinants of Diabetes, 973
Keri F. Kirk, Gerald McKinley, Briana Mezuk, and Erica Spears
Part 11 Diabetes in Special Groups
68 Ethnic, Cultural, and Religious Aspects to the Management of Diabetes, 987
Wasim Hanif, Sarah N. Ali, and Vinod Patel
69 Diabetes in Childhood, 999
Jennifer M. Ikle, Ananta Addala, and David M. Maahs
70 Adolescence and Emerging Adulthood: Diabetesin Transition, 1019
Charlotte W. Chen and Lori M.B. Laffel
71 Diabetes in Pregnancy, 1034
David R. McCance and Laura Cassidy
72 Diabetes in Old Age, 1072
Ahmed H. Abdelhafiz and Alan J. Sinclair
73 Diabetes at the End of Life, 1085
Trisha Dunning and June James
Part 12 Delivery and Organization of Diabetes Care
74 The Role of the Multidisciplinary Team across Primary and Secondary Care, 1097
Samuel Seidu and Kamlesh Khunti
75 Models of Diabetes Care in Low-and Middle-Income Countries, 1107
David Beran, Sigiriya Aebischer Perone, and Maria Lazo-Porras
Part 13 Future Directions
76 Immunotherapies for Type 1 Diabetes, 1125
Jesper Johannesen and Flemming Pociot
77 Stem Cell Therapy in Diabetes, 1137
Angelo Avogaro and Gian Paolo Fadini
78 Gene Therapy for Diabetes, 1144
Veronica Jimenez and Fatima Bosch
79 Future Drug Treatments for Type 2 Diabetes, 1154
Clifford J. Bailey
Index, 1167
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
diabetes; diabetes physiology; glucose homeostasis; islet function; insulin secretion; glucagon; Pathogenesis of diabetes; genetics of diabetes; diabetes obesity; autoimmune type 1 diabetes; drug-induced diabetes; diabetes reference
List of Contributors, viii
Preface, xv
List of Abbreviations, xvi
Part 1 Diabetes in its Historical and Social Context
1 The History of Diabetes Mellitus, 3
Robert B. Tattersall and David R. Matthews
2 Classification and Diagnosis of Diabetes, 22
Ambady Ramachandran, Chamukuttan Snehalatha, Arun Raghavan, and Arun Nanditha
3 The Global Burden of Diabetes, 28
Jessica L. Harding, Mary Beth Weber, and Jonathan E. Shaw
4 Epidemiology of Type 1 Diabetes, 41
Lars C. Stene and Jaakko Tuomilehto
5 Epidemiology of Type 2 Diabetes, 55
Ronald C.W. Ma and Peter C.Y. Tong
Part 2 Normal Physiology
6 Overview of Glucose Metabolism, 77
Richard I.G. Holt
7 Islet Function and Insulin Secretion, 84
Peter M. Jones and Shanta J. Persaud
8 Glucagon in Islet and Metabolic Regulation, 99
Jonathan E. Campbell and David A. D'Alessio
9 Mechanism of Insulin Action, 111
Morris F. White
10 Central Control of Glucose Homeostasis, 128
Kimberly M. Alonge, Kendra L. Francis, Nicole E. Richardson, and Michael W. Schwartz
11 Control of Body Weight: How and Why Do We Gain Weight Easier Than We Lose It?, 142
Janine Makaronidis and Rachel L. Batterham
Part 3 Pathogenesis of Diabetes
12 The Genetics of Diabetes, 157
Rashmi B. Prasad
13 Genetics of Obesity, 197
I. Sadaf Farooqi
14 Autoimmune Type 1 Diabetes, 203
Omar Akel and Ake Lernmark
15 Other Disorders with Type 1 Diabetes and Atypical Phenotypes, 216
Alice P.S. Kong, Elaine Y.K. Chow, Andrea O.Y. Luk, and Juliana C.N. Chan
16 Abnormalities of Insulin Secretion and ?-Cell Defects in Type 2 Diabetes, 225
Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele
17 Insulin Resistance in Type 2 Diabetes, 238
Michael Roden, Kitt Falk Petersen, and Gerald I. Shulman
18 Obesity and Diabetes, 250
Nick Finer
19 The Microbiome and Diabetes, 261
Amanda J. Cox, Nicholas P. West, and Allan W. Cripps
Part 4 Other Types of Diabetes
20 Monogenic Causes of Diabetes, 275
Brittany L. Resnick, Maggie H. Shepherd, and Andrew T. Hattersley
21 Drug-Induced Diabetes, 295
Charles D. Ponte and Devra K. Dang
22 Diabetes in Hypersecreting Endocrine Disorders, 304
Allan A. Vaag, Neil A. Hanley, and Caroline M. Kistorp
23 Pancreatic Disease and Diabetes, 319
Ranjit Unnikrishnan and Viswanathan Mohan
24 Clinical Presentations of Diabetes, 330
Ee Lin Lim and Roy Taylor
Part 5 Managing the Person with Diabetes
25 The Aims of Diabetes Care, 343
Katharine D. Barnard-Kelly and Richard I.G. Holt
26 Education to Empower the Person with Diabetes, 354
Ingrid Willaing and Michael Vallis
27 Dietary Management of Diabetes, 368
Nicola Guess
28 Physical Activities and Diabetes, 382
Emma J. Cockcroft and Robert C. Andrews
29 Monitoring Diabetes, 404
Emma English
30 Biomarkers and Precision Medicine in Diabetes, 414
Sok Cin Tye, Michele Provenzano, and Hiddo J.L. Heerspink
Part 6 Treatment of Diabetes
31 Insulin and Insulin Treatment, 431
Roman Vangoitsenhoven, Parth Narendran, and Chantal Mathieu
32 New Technologies for Glucose Monitoring, 444
Thomas Danne and Olga Kordonouri
33 New Technologies for Insulin Administration, 459
Hannah Forde and Pratik Choudhary
34 Whole Pancreas and Islet Cell Transplantation, 473
Braulio A. Marfil-Garza, Peter A. Senior, and A.M. James Shapiro
35 Oral Glucose-Lowering Agents, 492
Clifford J. Bailey and Andrew J. Krentz
36 Non-insulin Parenteral Therapies, 520
Tina Vilsboll, Mikkel Christensen, Andreas Andersen, and Filip K. Knop
37 How to Use Type 2 Diabetes Treatments in Clinical Practice, 534
Thomas Karagiannis, Aris Liakos, and Apostolos Tsapas
38 Weight Management and Metabolic Surgery, 551
Alexis Sudlow, Dimitri J. Pournaras, and Carel W. le Roux
39 In-Hospital Treatment and Surgery in People with Diabetes, 559
Ketan Dhatariya, Philip Newland-Jones, and Mayank Patel
40 Hypoglycaemia in Diabetes, 579
Ahmed Iqbal, Elaine Y.K. Chow, Timothy W. Jones, and Simon R. Heller
41 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycaemic State in Adults, 602
Philip Newland-Jones, Mayank Patel, and Ketan Dhatariya
Part 7 Microvascular Complications in Diabetes
42 Pathogenesis of Microvascular Complications, 615
Allan Flyvbjerg
43 Diabetic Retinopathy, 629
Toke Bek
44 Diabetic Nephropathy, 640
Peter Rossing and Allan Flyvbjerg
45 Diabetic Neuropathy, 655
Shazli Azmi, Uazman Alam, and Rayaz A. Malik
Part 8 Macrovascular Complications in Diabetes
46 Pathogenesis of Macrovascular Complications in Diabetes, 681
Jakob A. Ostergaard, Tomasz J. Block, Sophia Dahm, Waheed Khan, and Karin A.M. Jandeleit-Dahm
47 Hypertension and Diabetes, 700
Peter M. Nilsson
48 Dyslipidaemia and Diabetes, 713
Adie Viljoen, Ahmed Handhle, and Anthony S. Wierzbicki
49 Ischaemic Heart Disease in Diabetes, 724
Michael Lehrke and Nikolaus Marx
50 Heart Failure and Diabetes, 732
Ambarish Pandey, Kershaw V. Patel, and Subodh Verma
51 Cerebrovascular Disease and Diabetes, 745
Colum F. Amory, Jesse Weinberger, and Travis S. Smith
52 Peripheral Vascular Disease, 755
Henrik H. Sillesen
Part 9 Other Complications of Diabetes
53 Foot Problems in People with Diabetes, 771
Frank L. Bowling, Keeley J. Foley, and Andrew J.M. Boulton
54 Sexual Function in Men and Women with Diabetes, 780
Kirsty Winkley, Camilla Kristensen, Jackie Fosbury, and David Price
55 Gastrointestinal Manifestations of Diabetes, 796
Michael Camilleri and Adil E. Bharucha
56 Diabetes and Oral Health, 810
Palle Holmstrup, Christian Damgaard, and Allan Flyvbjerg
57 Diabetes and Non-alcoholic Fatty Liver Disease, 820
Alessandro Mantovani, Giovanni Targher, and Christopher D. Byrne
58 The Skin in Diabetes, 838
Paul Devakar Yesudian
59 Bone and Rheumatic Disorders in Diabetes, 853
Andrew Grey and Nicola Dalbeth
60 Diabetes and Cancer: Risk, Outcomes, and Clinical Implications, 867
Ellena Badrick, Emily J. Gallagher, and Andrew G. Renehan
61 Diabetes and Infections, 878
Andrea O.Y. Luk and Clive S. Cockram
62 Sleep and Diabetes, 897
Sonya Deschenes, Amy McInerney, and Norbert Schmitz
Part 10 Psychosocial Aspects of Diabetes
63 Psychosocial and Behavioural Aspects of Diabetes, 907
Frans Pouwer and Jane Speight
64 Role of Cognitive Function in Managing People with Diabetes, 922
Tamsin Santos, Chelsea Baird, Sally Eastwood, Kerrie Shiell, and Joseph E. Ibrahim
65 Mental Disorders and Diabetes, 933
Najma Siddiqi, Marietta Stadler, and Richard I.G. Holt
66 Social Aspects of Diabetes, 956
Brian M. Frier and Mark W.J. Strachan
67 Social Determinants of Diabetes, 973
Keri F. Kirk, Gerald McKinley, Briana Mezuk, and Erica Spears
Part 11 Diabetes in Special Groups
68 Ethnic, Cultural, and Religious Aspects to the Management of Diabetes, 987
Wasim Hanif, Sarah N. Ali, and Vinod Patel
69 Diabetes in Childhood, 999
Jennifer M. Ikle, Ananta Addala, and David M. Maahs
70 Adolescence and Emerging Adulthood: Diabetesin Transition, 1019
Charlotte W. Chen and Lori M.B. Laffel
71 Diabetes in Pregnancy, 1034
David R. McCance and Laura Cassidy
72 Diabetes in Old Age, 1072
Ahmed H. Abdelhafiz and Alan J. Sinclair
73 Diabetes at the End of Life, 1085
Trisha Dunning and June James
Part 12 Delivery and Organization of Diabetes Care
74 The Role of the Multidisciplinary Team across Primary and Secondary Care, 1097
Samuel Seidu and Kamlesh Khunti
75 Models of Diabetes Care in Low-and Middle-Income Countries, 1107
David Beran, Sigiriya Aebischer Perone, and Maria Lazo-Porras
Part 13 Future Directions
76 Immunotherapies for Type 1 Diabetes, 1125
Jesper Johannesen and Flemming Pociot
77 Stem Cell Therapy in Diabetes, 1137
Angelo Avogaro and Gian Paolo Fadini
78 Gene Therapy for Diabetes, 1144
Veronica Jimenez and Fatima Bosch
79 Future Drug Treatments for Type 2 Diabetes, 1154
Clifford J. Bailey
Index, 1167
Preface, xv
List of Abbreviations, xvi
Part 1 Diabetes in its Historical and Social Context
1 The History of Diabetes Mellitus, 3
Robert B. Tattersall and David R. Matthews
2 Classification and Diagnosis of Diabetes, 22
Ambady Ramachandran, Chamukuttan Snehalatha, Arun Raghavan, and Arun Nanditha
3 The Global Burden of Diabetes, 28
Jessica L. Harding, Mary Beth Weber, and Jonathan E. Shaw
4 Epidemiology of Type 1 Diabetes, 41
Lars C. Stene and Jaakko Tuomilehto
5 Epidemiology of Type 2 Diabetes, 55
Ronald C.W. Ma and Peter C.Y. Tong
Part 2 Normal Physiology
6 Overview of Glucose Metabolism, 77
Richard I.G. Holt
7 Islet Function and Insulin Secretion, 84
Peter M. Jones and Shanta J. Persaud
8 Glucagon in Islet and Metabolic Regulation, 99
Jonathan E. Campbell and David A. D'Alessio
9 Mechanism of Insulin Action, 111
Morris F. White
10 Central Control of Glucose Homeostasis, 128
Kimberly M. Alonge, Kendra L. Francis, Nicole E. Richardson, and Michael W. Schwartz
11 Control of Body Weight: How and Why Do We Gain Weight Easier Than We Lose It?, 142
Janine Makaronidis and Rachel L. Batterham
Part 3 Pathogenesis of Diabetes
12 The Genetics of Diabetes, 157
Rashmi B. Prasad
13 Genetics of Obesity, 197
I. Sadaf Farooqi
14 Autoimmune Type 1 Diabetes, 203
Omar Akel and Ake Lernmark
15 Other Disorders with Type 1 Diabetes and Atypical Phenotypes, 216
Alice P.S. Kong, Elaine Y.K. Chow, Andrea O.Y. Luk, and Juliana C.N. Chan
16 Abnormalities of Insulin Secretion and ?-Cell Defects in Type 2 Diabetes, 225
Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele
17 Insulin Resistance in Type 2 Diabetes, 238
Michael Roden, Kitt Falk Petersen, and Gerald I. Shulman
18 Obesity and Diabetes, 250
Nick Finer
19 The Microbiome and Diabetes, 261
Amanda J. Cox, Nicholas P. West, and Allan W. Cripps
Part 4 Other Types of Diabetes
20 Monogenic Causes of Diabetes, 275
Brittany L. Resnick, Maggie H. Shepherd, and Andrew T. Hattersley
21 Drug-Induced Diabetes, 295
Charles D. Ponte and Devra K. Dang
22 Diabetes in Hypersecreting Endocrine Disorders, 304
Allan A. Vaag, Neil A. Hanley, and Caroline M. Kistorp
23 Pancreatic Disease and Diabetes, 319
Ranjit Unnikrishnan and Viswanathan Mohan
24 Clinical Presentations of Diabetes, 330
Ee Lin Lim and Roy Taylor
Part 5 Managing the Person with Diabetes
25 The Aims of Diabetes Care, 343
Katharine D. Barnard-Kelly and Richard I.G. Holt
26 Education to Empower the Person with Diabetes, 354
Ingrid Willaing and Michael Vallis
27 Dietary Management of Diabetes, 368
Nicola Guess
28 Physical Activities and Diabetes, 382
Emma J. Cockcroft and Robert C. Andrews
29 Monitoring Diabetes, 404
Emma English
30 Biomarkers and Precision Medicine in Diabetes, 414
Sok Cin Tye, Michele Provenzano, and Hiddo J.L. Heerspink
Part 6 Treatment of Diabetes
31 Insulin and Insulin Treatment, 431
Roman Vangoitsenhoven, Parth Narendran, and Chantal Mathieu
32 New Technologies for Glucose Monitoring, 444
Thomas Danne and Olga Kordonouri
33 New Technologies for Insulin Administration, 459
Hannah Forde and Pratik Choudhary
34 Whole Pancreas and Islet Cell Transplantation, 473
Braulio A. Marfil-Garza, Peter A. Senior, and A.M. James Shapiro
35 Oral Glucose-Lowering Agents, 492
Clifford J. Bailey and Andrew J. Krentz
36 Non-insulin Parenteral Therapies, 520
Tina Vilsboll, Mikkel Christensen, Andreas Andersen, and Filip K. Knop
37 How to Use Type 2 Diabetes Treatments in Clinical Practice, 534
Thomas Karagiannis, Aris Liakos, and Apostolos Tsapas
38 Weight Management and Metabolic Surgery, 551
Alexis Sudlow, Dimitri J. Pournaras, and Carel W. le Roux
39 In-Hospital Treatment and Surgery in People with Diabetes, 559
Ketan Dhatariya, Philip Newland-Jones, and Mayank Patel
40 Hypoglycaemia in Diabetes, 579
Ahmed Iqbal, Elaine Y.K. Chow, Timothy W. Jones, and Simon R. Heller
41 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycaemic State in Adults, 602
Philip Newland-Jones, Mayank Patel, and Ketan Dhatariya
Part 7 Microvascular Complications in Diabetes
42 Pathogenesis of Microvascular Complications, 615
Allan Flyvbjerg
43 Diabetic Retinopathy, 629
Toke Bek
44 Diabetic Nephropathy, 640
Peter Rossing and Allan Flyvbjerg
45 Diabetic Neuropathy, 655
Shazli Azmi, Uazman Alam, and Rayaz A. Malik
Part 8 Macrovascular Complications in Diabetes
46 Pathogenesis of Macrovascular Complications in Diabetes, 681
Jakob A. Ostergaard, Tomasz J. Block, Sophia Dahm, Waheed Khan, and Karin A.M. Jandeleit-Dahm
47 Hypertension and Diabetes, 700
Peter M. Nilsson
48 Dyslipidaemia and Diabetes, 713
Adie Viljoen, Ahmed Handhle, and Anthony S. Wierzbicki
49 Ischaemic Heart Disease in Diabetes, 724
Michael Lehrke and Nikolaus Marx
50 Heart Failure and Diabetes, 732
Ambarish Pandey, Kershaw V. Patel, and Subodh Verma
51 Cerebrovascular Disease and Diabetes, 745
Colum F. Amory, Jesse Weinberger, and Travis S. Smith
52 Peripheral Vascular Disease, 755
Henrik H. Sillesen
Part 9 Other Complications of Diabetes
53 Foot Problems in People with Diabetes, 771
Frank L. Bowling, Keeley J. Foley, and Andrew J.M. Boulton
54 Sexual Function in Men and Women with Diabetes, 780
Kirsty Winkley, Camilla Kristensen, Jackie Fosbury, and David Price
55 Gastrointestinal Manifestations of Diabetes, 796
Michael Camilleri and Adil E. Bharucha
56 Diabetes and Oral Health, 810
Palle Holmstrup, Christian Damgaard, and Allan Flyvbjerg
57 Diabetes and Non-alcoholic Fatty Liver Disease, 820
Alessandro Mantovani, Giovanni Targher, and Christopher D. Byrne
58 The Skin in Diabetes, 838
Paul Devakar Yesudian
59 Bone and Rheumatic Disorders in Diabetes, 853
Andrew Grey and Nicola Dalbeth
60 Diabetes and Cancer: Risk, Outcomes, and Clinical Implications, 867
Ellena Badrick, Emily J. Gallagher, and Andrew G. Renehan
61 Diabetes and Infections, 878
Andrea O.Y. Luk and Clive S. Cockram
62 Sleep and Diabetes, 897
Sonya Deschenes, Amy McInerney, and Norbert Schmitz
Part 10 Psychosocial Aspects of Diabetes
63 Psychosocial and Behavioural Aspects of Diabetes, 907
Frans Pouwer and Jane Speight
64 Role of Cognitive Function in Managing People with Diabetes, 922
Tamsin Santos, Chelsea Baird, Sally Eastwood, Kerrie Shiell, and Joseph E. Ibrahim
65 Mental Disorders and Diabetes, 933
Najma Siddiqi, Marietta Stadler, and Richard I.G. Holt
66 Social Aspects of Diabetes, 956
Brian M. Frier and Mark W.J. Strachan
67 Social Determinants of Diabetes, 973
Keri F. Kirk, Gerald McKinley, Briana Mezuk, and Erica Spears
Part 11 Diabetes in Special Groups
68 Ethnic, Cultural, and Religious Aspects to the Management of Diabetes, 987
Wasim Hanif, Sarah N. Ali, and Vinod Patel
69 Diabetes in Childhood, 999
Jennifer M. Ikle, Ananta Addala, and David M. Maahs
70 Adolescence and Emerging Adulthood: Diabetesin Transition, 1019
Charlotte W. Chen and Lori M.B. Laffel
71 Diabetes in Pregnancy, 1034
David R. McCance and Laura Cassidy
72 Diabetes in Old Age, 1072
Ahmed H. Abdelhafiz and Alan J. Sinclair
73 Diabetes at the End of Life, 1085
Trisha Dunning and June James
Part 12 Delivery and Organization of Diabetes Care
74 The Role of the Multidisciplinary Team across Primary and Secondary Care, 1097
Samuel Seidu and Kamlesh Khunti
75 Models of Diabetes Care in Low-and Middle-Income Countries, 1107
David Beran, Sigiriya Aebischer Perone, and Maria Lazo-Porras
Part 13 Future Directions
76 Immunotherapies for Type 1 Diabetes, 1125
Jesper Johannesen and Flemming Pociot
77 Stem Cell Therapy in Diabetes, 1137
Angelo Avogaro and Gian Paolo Fadini
78 Gene Therapy for Diabetes, 1144
Veronica Jimenez and Fatima Bosch
79 Future Drug Treatments for Type 2 Diabetes, 1154
Clifford J. Bailey
Index, 1167
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