GPCRs as Therapeutic Targets

GPCRs as Therapeutic Targets

Gilchrist, Annette

John Wiley & Sons Inc

10/2022

1056

Dura

Inglês

9781119564744

15 a 20 dias

666

Descrição não disponível.
Chapter 1 - An overview of G protein coupled receptors and their signaling partners

Chapter 2 - Recent advances in orphan GPCRs research and therapeutic potential

Chapter 3 - The Evolution of Our Understanding of GPCRs

Chapter 4 - Approaching GPCR dimers and higher order oligomers using biophysical, biochemical and proteomic methods

Chapter 5 - Arrestin and G protein interactions with GPCRs: a structural perspective

Chapter 6 - GPCRs at endosomes: sorting, signaling, and recycling

Chapter 7 - Post-translational Control of GPCR Signaling

Chapter 8 - GPCR Signaling from Intracellular Membranes

Chapter 9 - Ten years of GPCR structures

Chapter 10 - Activation of class B GPCR by peptide ligands: general structural aspects

Chapter 11 - Dynamical basis of GPCR-G-protein coupling selectivity and promiscuity

Chapter 12 - Virtual Screening and Bioactivity Modeling for G Protein-Coupled Receptors

Chapter 13 - Importance of structure and dynamics in the rational drug design of

G protein-coupled receptor (GPCR) modulators

Chapter 14 - Signaling, Physiology and Targeting of GPCR-Regulated Phospholipase C Enzymes

Chapter 15 - G Protein-coupled Receptors in Metabolic Disease

Chapter 16 - Endothelin Receptors in cerebrovascular diseases

Chapter 17 - The calcium-sensing receptor (CaSR) in disease

Chapter 18 - G protein-coupled receptors and their mutations in cancer - a focus on adenosine receptors

Chapter 19 - Dopamine Receptors: Neurotherapeutic Targets for Substance Use Disorders

Chapter 20 - PTHR1 in bone

Chapter 21 - Activators of G-protein Signaling in the normal and diseased kidney

Chapter 22 - Screening and characterization of GPCR-ligand interactions with mass spectrometry-based technologies

Chapter 23 - Bioluminescence resonance energy transfer (BRET) technologies to study GPCRs

Chapter 24 - The Application of 19F NMR to Studies of Protein Function and Drug Screening

Chapter 25 - Chapter X: Optical Approaches for Dissecting GPCR Signaling

Chapter 26 - GPCR Signaling in Nanodomains: Lessons from Single-Molecule Microscopy
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